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Year Number of Results
2017 1
2018 4
2019 3
2020 2
2021 4
2022 2
2024 0

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15 results

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Page 1
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Cr… See abstract for full author list ➔ Gordon DE, et al. Among authors: kirby it. Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30. Nature. 2020. PMID: 32353859 Free PMC article.
Reversible ADP-ribosylation of RNA.
Munnur D, Bartlett E, Mikolčević P, Kirby IT, Rack JGM, Mikoč A, Cohen MS, Ahel I. Munnur D, et al. Among authors: kirby it. Nucleic Acids Res. 2019 Jun 20;47(11):5658-5669. doi: 10.1093/nar/gkz305. Nucleic Acids Res. 2019. PMID: 31216043 Free PMC article.
Rational design of selective inhibitors of PARP4.
Kirby IT, Person A, Cohen M. Kirby IT, et al. RSC Med Chem. 2021 Oct 4;12(11):1950-1957. doi: 10.1039/d1md00195g. eCollection 2021 Nov 17. RSC Med Chem. 2021. PMID: 34825190 Free PMC article.
Rational Design of Cell-Active Inhibitors of PARP10.
Morgan RK, Kirby IT, Vermehren-Schmaedick A, Rodriguez K, Cohen MS. Morgan RK, et al. Among authors: kirby it. ACS Med Chem Lett. 2018 Nov 29;10(1):74-79. doi: 10.1021/acsmedchemlett.8b00429. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655950 Free PMC article.
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Arnold MR, et al. Among authors: kirby it. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10. doi: 10.1016/j.chembiol.2022.11.006. Epub 2022 Dec 8. Cell Chem Biol. 2022. PMID: 36493759 Free article.
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
Reuschl AK, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J, Fabius JM, Nguyen GT, Swaney DL, Rosales R, White KM, Avilés P, Kirby IT, Melnyk JE, Shi Y, Zhang Z, Shokat KM, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. Reuschl AK, et al. Among authors: kirby it. bioRxiv [Preprint]. 2021 Feb 4:2021.01.24.427991. doi: 10.1101/2021.01.24.427991. bioRxiv. 2021. PMID: 33501437 Free PMC article. Preprint.
15 results